first science

the missing science, the theory of everything, and the arrow of time
Mathematical Physics has Important Limitations 

Since Sir Isaac Newton's Principia, published in 1687, mathematical physics has been upheld as the role model of science. Its ability to make accurate empirically verified predictions is unequalled. Although it has had great success, mathematical physics has a number of important limitations.

Mathematical physics transforms the qualitative world into a skeletal quantitative world. In this transformation, the Arrow of Time is lost as real time is transformed into mathematical time (see why).  As a result, mathematical physics cannot explain the whole of nature, since it cannot explain the Arrow of Time.  Furthermore, mathematical physics cannot explain irreducible, irreversible phenomena since they are manifestations of the Arrow of Time. 

Given these limitations, mathematical physics is unable to explain evolution, the self-organization of nature, and the unification of all the sciences.